تقييم المؤشرات الحيوية لوظائف الكلى لدى المرضى اليمنيين المصابين بثلاسيميا بيتا المعتمدين على نقل الدم

المؤلفون

DOI:

https://doi.org/10.67151/rujbas.v1i1.25

الكلمات المفتاحية:

ثلاسيميا، المعتمد على نقل الدم، علامات الكلى، زيادة الحديد، اليمن

الملخص

تُعد ثلاسيميا بيتا اضطرابًا وراثيًا في الدم يتميز بنقص في تخليق سلاسل بيتا جلوبين. وقد تتغير المؤشرات الحيوية الكلوية لدى المرضى المصابين بثلاسيميا بيتا المعتمدين على نقل الدم (TDT)  - وهي شكل حاد من ثلاسيميا بيتا - نتيجة لفرط حمل الحديد والعلاج بالاستخلاب. هدفت هذه الدراسة إلى تقييم المؤشرات الحيوية لوظائف الكلى (اليوريا، والكرياتينين، ومعدل الترشيح الكبيبي المقدر[eGFR]) لدى المرضى اليمنيين المصابين بثلاسيميا بيتا المعتمدين على نقل الدم. شملت الدراسة ثمانين مشاركاً تراوحت أعمارهم بين 2 و29 عاماً؛ حيث ضمت 40 مريضاً بثلاسيميا بيتا المعتمدين على نقل الدم  و40 شخصاً سليماً كمجموعة ضابطة. تم فحص عينات الدم لتحديد مستويات اليوريا، والكرياتينين، وتعداد الدم الكامل، ومؤشرات الحديد (Iron profile) باستخدام أجهزة تحليل آلية. أظهرت النتائج انخفاضاً معنوياً في مستويات اليوريا والكرياتينين لدى المرضى. وفي المقابل، كان معدل الترشيح الكبيبي المقدر (eGFR) المحسوب أعلى بكثير لدى مرضى ثلاسيميا بيتا المعتمدين على نقل الدم. كما ارتفعت مستويات حديد المصل وتشبع الترانسفيرين بشكل ملحوظ لدى المرضى. ارتبطت مستويات اليوريا ارتباطاً عكسياً (سلبياً) بالعمر (r = –0.345, p=0.03) وطردياً (إيجابياً) مع تعداد خلايا الدم الحمراء (r = 0.339, p=0.01)، في حين ارتبط الكرياتينين ارتباطاً طردياً بالعمر (r = 0.470, p=0.002) وعكسياً مع تركيز الهيموجلوبين في الكرية (MCHC) (r = –0.405, p=0.01). ثمة حاجة إلى إجراء المزيد من الدراسات، بما في ذلك تقييم المؤشرات الحيوية الكلوية المبكرة مثل البيتا 2-ميكروجلوبيولين البولي ونسبة الكالسيوم إلى الكرياتينين في البول، لتأكيد وجود إصابة كلوية دون سريرية لدى مرضى ثلاسيميا بيتا المعتمدين على نقل الدم.

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التنزيلات

منشور

2026-06-30

إصدار

القسم

المقالات

كيفية الاقتباس

تقييم المؤشرات الحيوية لوظائف الكلى لدى المرضى اليمنيين المصابين بثلاسيميا بيتا المعتمدين على نقل الدم. (2026). مجلة جامعة الرشيد للعلوم الأساسية والتطبيقية, 1(1), 14-23. https://doi.org/10.67151/rujbas.v1i1.25

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